Sync for Science

Sync for Science (S4S) is a public-private collaboration to develop a simplified, scalable, and secure way for individuals to access and share their electronic health record (EHR) data with researchers.

S4S supports the goals of the Precision Medicine Initiative (PMI) and is a collaboration among ONC, the Harvard Medical School Department of Biomedical Informatics, and the National Institutes of Health’s All of Us Research Program.

The Technology

S4S uses and builds upon open source standards that allow researchers to securely receive EHR data from a third-party application programming interface (API) used by a patient.

S4S standards include:

ONC’s Inferno testing tool allows developers to test APIs and ensure that they conform to the FHIR® standard. 

Ultimately, S4S makes it easier for health IT developers to participate in a mobile application ecosystem. S4S has helped accelerate and guide national priorities for individual-mediated data access and sharing through APIs.

The Pilot Project

S4S launched as a pilot project in February 2016, and participating sites were announced in 2017. Health IT developers involved in the pilot included:

  • Allscripts
  • Cerner
  • eClinicalWorks
  • Epic

Healthcare provider organizations that pilot-tested the S4S API included:

  • Cedars-Sinai Health System
  • Cerner Healthe Clinic
  • Duke University Health System
  • Partners HealthCare
  • Rush University Medical Center
  • University of Missouri Health Care

By participating in the pilot, provider organizations and health IT developers more quickly connected EHR systems to All of Us. The pilot activities also helped prepare provider organizations to use other emerging mobile apps that are based on HL7® FHIR®.

The pilot project concluded in 2019. Valuable lessons were learned, including how EHR developer and provider site involvement is critical to shaping the use of secure API technologies for real-world patient-directed sharing of EHR data.

Read more about the pilot project on our blog.

Expanding S4S

The Health Resources and Services Administration’s Advancing Precision Medicine funding has supported 46 health centers to participate in the All of Us direct volunteer program, which leverages S4S technology. Building on the success of the pilot, ONC worked with health IT developer NextGen Healthcare to participate in S4S, as they and other developers support health centers in the Advancing Precision Medicine program.

Advancing Interoperability and Research

The ONC and Centers for Medicare & Medicaid Services Cures Act Final Rules published in March 2020 require health IT developers and provider organizations to make it simpler for patients to access and share EHR data. The Final Rule updates existing 2015 Edition Health IT Certification Criteria for patient-facing APIs and uses the same standards and specifications that were demonstrated through the S4S pilot.

ONC plans to test additional data elements adopted under the U.S. Core Data for Interoperability as part of S4S.

The technology also supports the goals of ONC’s National Health IT Priorities for Research: A Policy and Development Agenda, released in February 2020, by improving access to interoperable electronic health data. The Agenda aims to align the clinical and research ecosystems to make research faster, better, and easier and ensure that new knowledge is available at the point of care to improve outcomes.

Learn more about S4S.

Content last reviewed on May 19, 2020
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