Precision Medicine


The Precision Medicine Initiative (PMI), launched in 2015, is a nationwide initiative to move away from the “one-size-fits-all” approach to health care delivery and to instead tailor treatment and prevention strategies to people’s unique characteristics, including environment, lifestyle, and biology.

Federal agencies and health care organizations advance the Precision Medicine Initiative by collaborating on projects in support of tailored medicine.

ONC Support for the PMI

  • Accelerating innovative collaboration that supports health IT interoperability for research through pilot projects and testing of standards
  • Adopting policies and standards to support the privacy and security of cohort participant data
  • Advancing standards that support participant-driven data contribution

Read more about ONC’s activities supporting the PMI on our blog.



ONC’s Current PMI Activities

Sync for Science

This public-private collaboration aims to develop a simplified, scalable, and secure way for individuals to access and share their electronic health record data with researchers.

Sync for Genes

This project aims to standardize the sharing of genomic information among laboratories, providers, patients, and researchers and to advance the development and use of industry-supported standards for genomic data.

Advancing Standards for Precision Medicine

This project is working to make health data easier to share, curate, aggregate, and synthesize by focusing on standards in mobile health, sensors, and wearable data as well as social determinants of health data.

ONC’s Completed PMI Activities

API Privacy and Security Considerations

This report discusses key considerations for the privacy and security of healthcare application programing interfaces (APIs), based on Sync for Science pilot project activities.

Data Security Principles

This implementation guide outlines best practices in security and data management for precision medicine. The guide was designed for organizations participating in the PMI or working with its resulting data.

Related Federal Programs and Projects

ONC Patient-Centered Outcomes Research

In collaboration with multiple federal agencies, ONC has led a series of key projects that advance policy, standards, and services necessary to expand the data infrastructure for patient-centered outcomes research, which ensures patient decisions are incorporated into research and care recommendations.

All of Us Research Program

The National Institutes of Health (NIH) leads this national effort to gather data from one million or more people in the United States to help researchers develop tailored treatments and prevent disease through precision medicine.

All of Us logo


This online, cloud-based portal will allow scientists from industry, academia, government, and other partners to come together and innovate.

Precision FDA logo

Million Veteran Program

This program aims to build one of the world’s largest, secure medical databases by safely collecting blood samples and health information from one million veteran volunteers, enabling research on how genes affect certain diseases and military-related illnesses.

million veteran program

Big Data Science Initiative

The U.S. Department of Veteran Affairs and the Department of Energy have partnered for this initiative to help advance healthcare and next-generation supercomputing designs.

US department of veterans health administration