Precision Medicine


The Precision Medicine Initiative (PMI), launched in 2015, is a nationwide initiative to move away from the “one-size-fits-all” approach to health care delivery and to instead tailor treatment and prevention strategies to people’s unique characteristics, including environment, lifestyle, and biology.

Federal agencies and health care organizations advance the Precision Medicine Initiative by collaborating on projects in support of tailored medicine.

ONC's Role in PMI

  • Accelerate innovative collaboration around pilots and testing of standards that support health IT interoperability for research
  • Adopt policies and standards to support privacy and security of cohort participant data
  • Advance standards that support a participant-driven approach to patient data contribution

ONC's Precision Medicine Initiative Activities

​​​​​​Ongoing Activities

  • Sync for Science (S4S):
    Sync for Science™ (S4S) is a public-private collaboration to demonstrate and accelerate the adoption of application programming interfaces (APIs) that gives individuals an automated method to share their clinical data with research and consumer health applications of their choice.
  • Sync for Genes:
    Sync for Genes is the first step toward making clinical genomics available at the point of care by expediting the use of standards that support the sharing and integration of genomic information.
  • Advancing Standards for Precision Medicine:
    Advancing Standards for Precision Medicine is the first step toward standardizing wearable, sensor, and social determinants of health data for research and care.

    Concluded Activities

    • Sync for Science API Privacy and Security:
      Led an independent privacy and security technical and administrative testing, analysis, and assessment of a voluntary subset of S4S pilot organizations’ implementations of the S4S API. Read to learn more about some key privacy and security considerations for healthcare APIs, informed by project activities.
    • Precision Medicine Initiative Data Security Principles Implementation Guide:
      The guide provides best practices in security and data management for precision medicine for organizations participating in the program or working with resulting data.

    Related Programs

    ONC PCOR Projects
    ONC, in collaboration with multiple HHS agencies, has led a series of key projects that collectively develop policy, standards, and services necessary to expand the data infrastructure for patient-centered outcomes research. This work, funded by the Patient-Centered Outcomes Research Trust Fund (PCORTF), supports precision medicine by ensuring patient decisions are incorporated into research and care recommendations that best align with patient needs. Read more on PCOR.

    Other Federal Government PMI Programs

    All of Us logo


    • All of Us Research Program:
      The National Institutes of Health (NIH) leads this historic effort to gather data from one million or more people living in the United States to accelerate research and improve health through the delivery of precision medicine.

    Precision FDA logo

    • precisionFDA:
      precisionFDA is an online, cloud-based, portal that will allow scientists from industry, academia, government and other partners to come together to foster innovation and develop the science behind a method of “reading” DNA known as next-generation sequencing (or NGS). Blog post on precisionFDA.

    million veteran program

    • Million Veteran Program (MVP)
      MVP is a national, voluntary research program funded entirely by the Department of Veterans Affairs Office of Research & Development. The goal of MVP is to partner with Veterans receiving their care in the VA Healthcare System to study how genes affect health. To do this, MVP will build one of the world's largest medical databases by safely collecting blood samples and health information from one million Veteran volunteers. Data collected from MVP will be stored in a secure manner and will be coded for researchers so that they cannot directly identify you. Researchers will study diseases like diabetes and cancer, and military-related illnesses, such as post-traumatic stress disorder.
    • Big Data Science Initiative:
      US Department of Veteran Affairs (VA) and the Department of Energy (DOE) have partnered for the VA-DOE Big Data Science Initiative to help advance health care for Veterans and others in areas such as suicide prevention, cancer and heart disease, while also driving DOE’s next-generation supercomputing designs. Through a project called - MVP-CHAMPION— short for the Million Veteran Program (MVP) Computational Health Analytics for Medical Precision to Improve Outcomes Now.
    Content last reviewed on July 3, 2019
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