Application programming interfaces (APIs) are powerful tools that help support interoperability in healthcare. Simply put, APIs allow a software “Application A” to interact with a software “Application B” without Application A needing to know how Application B’s software is designed internally. APIs can be used for several things, including the ability to for software applications to share information. From the example above, Application A could request information from Application B or ask Application B to place a pushpin on a map at a specific longitude and latitude. In other words, think of an API like a “data concierge.” API-based exchanges have become commonplace in our everyday life, from mobile banking to booking a plane ticket, from downloading media to shopping online. Naturally, as adoption of electronic health records (EHRs) continues to expand, it is essential for APIs to play an increasing role with respect to healthcare interoperability.