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Clinical Quality Framework Pilot - Phentotype Execution and Modeling Architecture

Phentotype Execution and Modeling Architecture

Pilot Background:
The identification of patient cohorts for clinical and genomic research is a costly and time-consuming process. This bottleneck adversely affects public health by delaying research findings, and in some cases by making research costs prohibitively high. To address this issue, leveraging electronic health records (EHRs) for identifying patient cohorts has become an increasingly attractive option. With the rapidly growing adoption of EHR systems due to Meaningful Use, and linkage of EHRs to research biorepositories, evaluating the suitability of EHR data for clinical and translational research is becoming ever more important, with ramifications for genomic and observational research, clinical trials, and comparative effectiveness studies. A key component for identifying patient cohorts in the EHR is to define inclusion and exclusion criteria that algorithmically select sets of patients based on stored clinical data. This process is commonly referred to as “EHR-driven phenotyping”. Phenotypes are defined over both structured data (demographics, diagnoses, medications, lab measurements) as well as unstructured clinical text (radiology reports, encounter notes, discharge summaries). Phenotyping logic can be quite complex, and typically includes both Boolean and temporal operators applied to multiple clinical events. In general, the phenotyping algorithm development process is a multi-disciplinary team effort, including clinicians, domain experts, and informaticians, and is operationalized as database queries and software, customized to the local EHR environment. The typical way to share phenotyping algorithms across institutions is through the use of informal free text descriptions of algorithm logic, possibly augmented with graphical flowcharts and simple lists of structured codes. This is due to the lack of a widely accepted and standards-based formal information model for defining phenotyping algorithms. However, implementing a phenotyping algorithm from a free-text description is itself an error-prone and time-consuming process, due to the inherent ambiguities of free text as well as the necessity for human intermediaries to map algorithmic criteria expressed as free text to database queries and code.
Start Date
Projected End Date
Project Tags
  • CDS
  • CQF
  • CQL
Project Point of Contact:
Project Results