The Electronic Prescribing of Controlled Substances is on the rise

Over the past couple of years, EPCS – the electronic prescribing of controlled substances – has increased dramatically. This has potential benefits for both patients and health care system costs.

Now, thanks to health information technology tools, patients in nearly all 50 states can have their medications prescribed electronically. Electronic prescribing also has the potential to reduce costs to the overall health care system by curbing drug diversions (theft) of controlled substances. According to the HHS Inspector General, the Medicare Prescription Drug Program paid pharmacies $25 million for Schedule II drugs billed as refills in 2009. This was a red flag, the OIG found, because “in no circumstances is Medicare supposed to pay for refills of these drugs.” Using electronic prescribing technology, providers can now also closely track electronic prescriptions of controlled substances through prescription drug monitoring programs (PDMP).

Current estimates show that controlled substances comprise 12 percent of all prescriptions made each year. Because these drugs have potential for abuse, dependence, and overdose, electronic prescribing (e-prescribing) was unavailable until the Drug Enforcement Administration legalized it in 2010. Since then, the number of electronic prescriptions has continued to climb, a benefit to many patients and their health care providers.  We co-authored a new study published in the American Journal for Managed Care looking at 18 months of transactional data depicting the EPCS growth in both pharmacies and providers.

Number of e-prescribers increased from 225 in July 2012 to 5101 in December 2013

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On average, the total number of EPCS increased by nearly 3,000 prescriptions every month during the study period.

In July 2012 1 in 10 pharmacies pharmacies is EPCS-enabled, and by December 2013, nearly one-third of U.S. pharmacies were enabled to accept EPCS.

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We found, on average, the total number of EPCS-enabled pharmacies increased by nearly 700 pharmacies every month. By December 2013, nearly one-third of U.S. pharmacies were enabled to accept EPCS.

Number of e-prescriptions increased from 1,535 in July 2012 to 52,423 in December 2013

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We also found the growth in EPCS among providers (physicians, physician assistants and nurse practitioners) is steadily increasing. In fact, we found that an average of nearly 300 new providers sent EPCS every month.

However, there are challenges that providers face in using EPCS including system security compliance, provider authentication issues, and regulatory hurdles.

Deaths from drug overdoses have increased 117%. Therefore, addressing opioid use disorder is a high priority for the Department of Health and Human Services.  The Department’s goal around opioids is to maximize our ability to deliver impact to the American people through evidence-based strategies that decrease opioid overdoses and overdose-related mortality and decrease the prevalence of opioid use disorder. These include expanded use of PDMPs and integration with health IT systems.

As we move toward better health and health care at lower costs, the growth of EPCS highlights one opportunity to support safer use and management of prescription medications, including controlled substances. As the growth of EPCS continues to increase, we are committed to continue to work with public health officials to address opioid related use and overdose through a variety of programs and coordination efforts.


  1. Admir says:

    The idea of electronic delivery of subscriptions of controlled substances has its pros and cons. For the ones that need these medications for health reasons and actually take them because they need to will have increased convenience and avoid the drive to their doctor.

    Unfortunately, drug addicts and what not can take advantage of this in a negative way.

  2. Dave Newman says:

    Thanks for the article Tricia. My org hasn’t quite jumped on, only because of the biometric requirements and the competition for IT staff working on a multitude of other projects. It would be nice to see some more detailed analysis on how long it takes organizations to break even after the investment in the equipment and implementation costs.

  3. Rick Camp says:

    Nice article. I know we provided you some of the data for the publication. Each month w update our tracking report on the national and state level of EPCS enablement. As of January 1, 2015 about 70% of pharmacies and 4% of providers are enabled for EPCS. This number varies greatly by State. The adoption effort on the provider side requires several more steps than the pharmacy side and physicians need to be educated on what they can and must do. We just finished a video to explain this and how doctors can work with their EHR to get EPCS. We’d be glad to share the educational video with you on this topic. It will become available to the public next week at

    Feel free to contact me if you’d like to learn more or work with me on the EPCS education I will continue to be rolling out. Thanks.

    Rick Camp
    Marketing Director, Surescripts

    • Ms Micki Dooley says:

      We continue to receive calls from pharmacists who claim they cannot fill the RX from EPCS. we have to call them and give verbal approval. (Express scripts moat recently)
      All of our providers are enrolled in Surescipts and our EHR vendor is NextGen. I’d be very interested in the video you mentioned from you January 2015 post.

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